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HomeHealth & MedicineMarried People with Cancer Live Longer

Married People with Cancer Live Longer

The deadly disease cancer evolves from gene mutations. However, convincing evidence supports the idea that married cancer patients live longer because of the personal and emotional support of the marital union.

Cancer is a genetic disease. Mutation or specific gene changes convert normal cells into cancer cells by accelerating cell growth and inhibiting programmed cell death.

In Canada, cancer remains the leading cause of death. According to Canadian Cancer Statistics, an estimated 2 in 5 Canadian are diagnosed with cancer, and one-fourth of the total population dies from this disease (Brenner, Poirier, et al. 2022). Despite the improvement in cancer treatment, cancer incidence continues to grow. Therefore, it is essential to understand the factors that affect the prognosis of the disease.

Globally, of the total population, 67% are married, which is only 50% in the USA, and the trend of being unmarried is gradually increasing. Since marriage has been described as one of the most powerful predictors of well-being and positive mental health (Gove, Hughes, et al. 1983), the relationship between marital status and cancer prevention is worthy of investigation.

Protective Effect of Marriage on Health

Marital status has an enormous role in protective health effects on survival (Rendall, Weden, et al. 2011).

Israel-based longitudinal studies involving 152,150 and 209,125 individuals during the period (1983-1992) and (1995-2004), respectively, have calculated mortality inequalities based on marital status (Jaffe, Manor, et al. 2007). In the studies, marital status appeared to be a significant factor in mortality inequalities which widened over time for middle-aged and older adults.

Being married has been shown to lower the risk of dementia (Sommerlad, Ruegger, et al. 2018), have a strong positive effect on longevity (Gardner and Oswald 2004), and have positive, healthy behaviors (Schone and Weinick 1998).

A systematic review involving 34 studies with more than two million participants showed that unmarried status is associated with an increased risk of cardiovascular diseases, coronary heart diseases, myocardial infarction, and stroke-related death (Wong, Kwok, et al. 2018). On the other hand, being married was 2.5 times more likely to be alive 15 years after coronary artery bypass surgery (King and Reis 2012).

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Impact of Marital Status on Cancer Survival

Studies have long shown that married people with cancer live longer than unmarried people.

In 1987, Goodwin et al. examined the effects of marital status on the diagnosis, treatment, and survival of patients with cancer in population-based data on 27,779 cancer cases and found that unmarried people had decreased overall survival (relative hazard, 1.23) (Goodwin, Hunt, et al. 1987).

A Norwegian study investigated 100,000 deaths during the period 1960-91 and compared all-cause excess mortality among cancer patients with the death in the absence of cancer. The study found a 15% higher for the never-married individual than unmarried people (Kravdal 2001).

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Data collected from 261,070 patients with late-stage cancer at multiple sites in the United States showed that married patients with cancers of all major primary sites had significantly better survival than single, separated, divorced, or widowed patients (Lai, Lai, et al. 1999).

Analyzing data collected from Surveillance, Epidemiology, and End Results (SEER) cancer registry database, several recent reports identified social factors, particularly marital status, as an independent factor in the progression of cancer and cancer-related mortality (Du, Zhan, et al. 2022, Jiao, Ma, et al. 2022, Wu, Zhu, et al. 2022).

Scientists from the University of California San Diego School of Medicine and Fremont’s Cancer Prevention Institute of California analyzed the data of 783,167 cancer patients. They found that the risk of death was 27 percent greater for unmarried men who have developed the disease than for married men and 19 percent higher for unmarried women. After correcting for socioeconomic differences, they still found that unmarried men were 22 percent more likely to succumb to cancer and unmarried women 15 percent more likely to die. The result of the study was published in CANCER, a journal of the American Cancer Society (Gomez, Hurley, et al. 2016).

cancer-death: married vs unmarried
Source: Cancer. 2016 May 15; 122(10): 1618–1625.

A SEER study selected 6627 people from 2004 to 2013 to study gallbladder cancer (GBC) patients. The study found that GBC married patients had significantly higher survival (20.1%) than unmarried GBC (17.8%). However, the risk of death of widowed women increases more than that of single women. The result was published in a famous nature journal (Li, Liu, et al., 2017).

Science Behind the Survival Advantage

The explanations behind the survival advantage of being married are the early cancer diagnosis, receiving recommended or aggressive therapy, a higher economic status, and better social support. The unmarried person is most probably diagnosed at a distant stage, remains untreated for longer, and suffers from poor economic and social status.

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Experts say that the role of a partner’s emotional support is crucial to survival. A married individual usually takes special care of his health and his partner. The married man is usually not careless. He needs to take special care of his health and his partner.

Dr. Gomez, the first author of the Nature study, stated in a press release, “Our study provides evidence for social support as a key driver” behind the survival advantage of married cancer patients.

Diagnosis and treatment are faster in married people. Post-treatment follow-up is also essential. In these respects, married people are ahead of unmarried people in most cases, so they have a higher survival rate from the disease.

Despite some conflicting reports that show a lower risk of death from cancer in married people compared to unmarried ones does not apply to all cancers, many studies support the idea that the psychological and emotional support of married cancer patients plays a significant role in the survival other than the active treatment for primary diseases.

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References

Brenner, D. R., A. Poirier, et al. (2022). “Projected estimates of can-cer in Canada in 2022.” CMAJ 194(17): E601-E607. ‘10.1503/cmaj.212097’.
Du, X., W. Zhan, et al. (2022). “Marital status and survival in laryngeal squamous cell carcinoma patients: a multinomial propensity scores matched study.” Eur Arch Otorhinolaryngol 279(6): 3005-3011. ‘10.1007/s00405-022-07252-7’.
Gardner, J. and A. Oswald (2004). “How is mortality affected by money, marriage, and stress?” J Health Econ 23(6): 1181-1207. ‘10.1016/j.jhealeco.2004.03.002’.
Gomez, S. L., S. Hurley, et al. (2016). “Effects of marital status and economic resources on survival after can-cer: A population-based study.” Cancer 122(10): 1618-1625. ‘10.1002/cncr.29885’.
Goodwin, J. S., W. C. Hunt, et al. (1987). “The effect of marital status on stage, treatment, and survival of can-cer patients.” JAMA 258(21): 3125-3130.
Gove, W. R., M. Hughes, et al. (1983). “Does marriage have positive effects on the psychological well-being of the individual?” Journal of health and social behavior: 122-131.
Gove, W. R., M. Hughes, et al. (1983). “Does marriage have effects on the psychological well-being of the individual?” Journal of health and social behavior: 122-131.
Jaffe, D. H., O. Manor, et al. (2007). “The protective effect of marriage on mortality in a dynamic society.” Ann Epidemiol 17(7): 540-547. ‘10.1016/j.annepidem.2006.12.006’.
Jiao, D., Y. Ma, et al. (2022). “Impact of Marital Status on Prognosis of Patients With Invasive Breast Can-cer: A Population-Based Study Using SEER Database.” Front Oncol 12: 913929. ‘10.3389/fonc.2022.913929’.
King, K. B. and H. T. Reis (2012). “Marriage and long-term survival after coronary artery bypass grafting.” Health Psychol 31(1): 55-62. ‘10.1037/a0025061’.
Kravdal, O. (2001). “The impact of marital status on cancer survival.” Soc Sci Med 52(3): 357-368. ‘10.1016/s0277-9536(00)00139-8’.
Lai, H., S. Lai, et al. (1999). “The effect of marital status on survival in late-stage can-cer patients: an analysis based on surveillance, epidemiology, and end results (SEER) data, in the United States.” Int J Behav Med 6(2): 150-176. ‘10.1207/s15327558ijbm0602_4’.
Li, X., Y. Liu, et al. (2017). “The influence of marital status on survival of gallbladder can-cer patients: a population-based study.” Sci Rep 7(1): 5322. ‘10.1038/s41598-017-05545-0’.
Rendall, M. S., M. M. Weden, et al. (2011). “The protective effect of marriage for survival: a review and update.” Demography 48(2): 481-506. ‘10.1007/s13524-011-0032-5’.
Schone, B. S. and R. M. Weinick (1998). “Health-Related Behaviors and the Benefits of Marriage for Elderly Persons.” The Gerontologist 38(5): 618-627. ‘10.1093/geront/38.5.618’.
Sommerlad, A., J. Ruegger, et al. (2018). “Marriage and risk of dementia: systematic review and meta-analysis of observational studies.” Journal of Neurology, Neurosurgery & Psychiatry 89(3): 231-238. ‘10.1136/jnnp-2017-316274’.
Wong, C. W., C. S. Kwok, et al. (2018). “Marital status and risk of cardiovascular diseases: a systematic review and meta-analysis.” Heart 104(23): 1937-1948. ‘10.1136/heartjnl-2018-313005’.
Wu, Y., P. Z. Zhu, et al. (2022). “Relationship between marital status and survival in patients with lung adenocarcinoma: A SEER-based study.” Medicine (Baltimore) 101(1): e28492. ‘10.1097/MD.0000000000028492’.

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