Friday, January 27, 2023
HomeHealth & MedicineFrequent Use of Painkillers Associated with Higher Risk of Tinnitus in Women

Frequent Use of Painkillers Associated with Higher Risk of Tinnitus in Women

According to a new study from Brigham and Women’s Hospital, regular use of pain relievers such as aspirin, acetaminophen, and ibuprofen is connected with an increased incidence of tinnitus in women.

A recent study from Brigham and Women’s Hospital shows frequent use of painkillers such as Aspirin, Acetaminophen, and Advil is associated with a higher risk of tinnitus in women.

The study investigated clinical data collected from 69,455 women over a period of over 20 years to evaluate if long-term use of pain medications has any impact on tinnitus.

The study result is published recently in the Journal of Internal Medicine (Curhan, Glicksman, et al. 2022).

The term ‘tinnitus’ defines experiencing sounds—ringing, hissing, buzzing, rushing, or roaring —in the absence of an external sound not heard by other people. The perception common in older adults, affecting about 15% to 20% of people, adversely impacts daily lives, including sleep, work, communication, and quality of life.

An estimated 50 million U. S adults suffer from tinnitus, among whom 3 million have it almost daily (Shargorodsky, Curhan, et al. 2010).

A 2019 Statistics Canada report shows around a third of adult Canadians experienced tinnitus, with around seven percent categorizing the problem as “bothersome” (Ramage-Morin, Banks, et al. 2019).

The exact pathophysiology of tinnitus is unknown, but many factors, including hearing loss, exposure to loud noise, neurological injuries, dental disorders, and certain infectious diseases, may precipitate tinnitus.

In the new study, the researchers investigated if there is an independent association between taking pain medicine such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), and acetaminophen and the risk of persistent tinnitus.

For this purpose, the scientists used data from the Nurses Health Study II, a long-term study that examines causes and risk factors and the long-term effects of nutrition, hormones, environment, and nurses’ work-life on health and disease development.

Out of this cohort, the researchers examined data of 69,455 women aged 31 to 48 years at the time of enrollment and were followed up over 20 years. Women were asked to answer various health-related questions once every two years to track their health over a long period.

tinnitus

Participants answered questions about their use of over-the-counter pain medications and the use of COX-2 inhibitors, prescription NSAIDs with similar properties to other NSAIDS but with fewer gastrointestinal side effects.

In the cohort, the researchers found 10,452 cases of persistent tinnitus.

The team also observed the following:

  • Frequent use (6-7 days per week) and moderate-dose aspirin increased the risk of tinnitus by 16 percent among participants aged less than 60 but not among older participants.
  • Frequent but low-dose aspirin (≤100 mg) was not associated with an increased risk of tinnitus.
  • Frequent use of both NSAIDs or acetaminophen increased the risk by almost 20 percent or more.
  • Moderate use (2 or more days per week) of COX-2 inhibitors was linked with a 20 percent greater risk of developing tinnitus as well.

“Our findings suggest that analgesic users may be at higher risk for developing tinnitus and may provide insight into the precipitants of this challenging disorder,” said lead author Sharon Curhan, MD, ScM, of the Brigham’s Channing Division of Network Medicine.

“Even though these analgesics are widely available without a prescription, these are still medications, and there are potential side effects. For anyone considering taking these types of medications regularly, it is advisable to consult with a health care professional to discuss the risks and benefits and explore whether there are alternatives to using medication.”

The study didn’t investigate the causes for increasing the risk of tinnitus, so it’s not yet known if the use of pain medications is a cause of tinnitus or is another side effect of something unknown.

One major limitation of this study was that most of the participants involved in the study were white women, showing more analysis is needed on non-white women and men.

Related Publication and Further Readings

Curhan, S. G., J. Glicksman, et al. (2022). “Longitudinal Study of Analgesic Use and Risk of Incident Persistent Tinnitus.” J Gen Intern Med.

Ramage-Morin, P. L., R. Banks, et al. (2019). “Tinnitus in Canada.” Health Rep 30(3): 3-11.

Shargorodsky, J., G. C. Curhan, et al. (2010). “Prevalence and characteristics of tinnitus among US adults.” Am J Med 123(8): 711-718.

1 COMMENT

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Recent Post

Human-DNA-Gene-Organ

Time-Restricted Eating Reshapes Gene Expression Throughout the Body

0
Timed caloric intake synchronizes circadian rhythms across several systems in mice by influencing numerous gene expressions, found researchers at Salk Institute Key Points: Time- restricted eating...

MOST COMMENTED

fitness-vegan-exercise

For Weight Loss, Vegan Is Better Than the Mediterranean Diet

51
Vegan is more effective for weight loss, cholesterol control, body composition, and insulin sensitivity, when compared head to head with Mediterranean diet.

RECENT UPDATE

Supplement Boosts Muscle, Mitochondria Health

An oral supplement intended to stimulate a natural body process appears to promote muscle endurance and mitochondrial health in humans.

Common Food Colorings Can Trigger Inflammatory Bowel Diseases

According to Waliul Khan of McMaster University, long-term ingestion of the food color Allura Red may promote inflammatory bowel disorders (IBDs), Crohn's disease, and...

Illegal Gold Mining Turns Pristine Rainforests into Mercury Sinks

Illegal gold mining in the Peruvian amazon turns pristine rainforests into heavily polluted mercury sinks--reports a new study.

Amazon Rainforest Is Losing Resilience: New Evidence from Satellite Data Analysis

Amazon rainforest is losing its resilience and the rainforest now shows characteristic signs of approaching a tipping point.

Avocados Change Belly Fat Distribution in Women

An avocado a day could help redistribute belly fat in women toward a healthier profile, reports a new study from the University of Illinois.